Specific changes in the M1 protein during adaptation of influenza virus to mouse
Identifieur interne : 001D38 ( Main/Exploration ); précédent : 001D37; suivant : 001D39Specific changes in the M1 protein during adaptation of influenza virus to mouse
Auteurs : A. C. Ward [Australie]Source :
- Archives of Virology [ 0304-8608 ] ; 1995-02-01.
English descriptors
- Teeft :
- Acid change, Acid substitution, Acid substitutions, Amino, Amino acids, Control virulence, Determinant, Direct sequencing, Gene, Gene sequences, Growth rate, Host range restriction, Influenza, Influenza virus, Matrix, Matrix protein, Mouse, Mouse brain, Mouse lung, Neurovirulent, Neurovirulent strains, Nucleic acids, Nucleotide, Nucleotide sequence, Other strains, Proc natl acad, Protein sequences, Royal melbourne hospital, Sequence changes, Substitution, Virol, Virology, Virulence, Virus.
Abstract
Summary: The matrix (M) gene of influenza virus has been implicated as a determinant of virulence for mouse brain and lung. Comparison of the M gene sequences of the mouse brain adapted variants A/NWS/33 and A/WSN/33 to their parent, A/WS/33, identified two specific amino acid substitutions in the M1 protein which correlated with virulence for mouse: Ala41 → Val and Thr139 → Ala.
Url:
DOI: 10.1007/BF01309872
Affiliations:
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Le document en format XML
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